Neural Stimulation

Figure of model recruitment of neuronal pathways.

We study the biophysics of the interactions between extracellular electric fields and neurons. Specifically, the electric fields generated by electrodes implanted in brain tissue and how they modulate the firing of nearby neurons.

Bower KL, Noecker AM, Frankemolle-Gilbert AM, McIntyre CC. Model-Based Analysis of Pathway Recruitment During Subthalamic Deep Brain Stimulation. Neuromodulation. 2023 Apr 25:S1094-7159(23)00140-X. doi: 10.1016/j.neurom.2023.02.084. Epub ahead of print. PMID: 37097269.

Bingham CS, McIntyre CC. Subthalamic deep brain stimulation of an anatomically detailed model of the human hyperdirect pathway. J Neurophysiol. 2022 May 1;127(5):1209-1220. doi: 10.1152/jn.00004.2022. Epub 2022 Mar 23. PMID: 35320026; PMCID: PMC9054256.

Noecker AM, Frankemolle-Gilbert AM, Howell B, Petersen MV, Beylergil SB, Shaikh AG, McIntyre CC. StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease. Neuromodulation. 2021 Feb;24(2):248-258. doi: 10.1111/ner.13350. Epub 2021 Jan 3. PMID: 33389779; PMCID: PMC8581744.